OXYETHYL SULFONE-3-METHYL-5-PYRAZOLONE

PRODUCT IDENTIFICATION

CAS NO. 21951-34-8

OXYETHYL SULFONE PYRAZOLONE

EINECS NO. 244-678-8
FORMULA C12H14N2O4S
MOL WT. 282.31

H.S. CODE

 

TOXICITY

 
SYNONYMS

1-[4-(2- Hydroxyethylsulfonyl)phenyl]-3-methyl-5-pyrazolone;

2,4-Dihydro-2-[-4-[(2-hydroxyethyl)sulfonyl] phenyl]-5-methyl-3H-pyrazol-3-one;
SMILES

 

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to off-white powder

MELTING POINT

 
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REFRACTIVE INDEX

 
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FLASH POINT  
STABILITY Stable under ordinary conditions.

APPLICATIONS

Pyrazolone is a five-membered lactam ring compound containing two nitrogens and ketone in the same molecule. Lactam structure is an active nucleuses in pharmacological activity. Pyrazolone is an active moiety as a pharmaceutical ingredient, especially in the class of nonsteroidal antiinflammatory agents used in the treatment of arthritis and other musculoskeletal and joint disorders.

The term of pyrazolone sometimes refers to nonsteroidal anti-inflammatory agents.  Pyrazolone class NSAID (nonsteroidal anti-inflammatory drug) includes phenylbutazone, oxyphenbutazone, dipyrone, and ramifenazone. Antipyrine (also called phenazone) is a pyrazolone class analgesic agent in otic solutions in combination with other analgesic such as benzocaine, and phenylephrine.

Antipyrine has been used as an antipyretic, but replaced due to the possibility of agranulocytosis side effect. Lactams have big demand in artificial fibre industry. Pyrazolone derivatives, as lactam structure related compounds, are also widely used in preparing dyes and pigments. 4-Aminoantipyrine possibly can be used as an intermediate for the synthesis of pharmaceuticals especially antipyretic and analgesic drugs. It is also used in the colorimetric determination of phenols.

Amidopyrine is used in manufacturing drugs especially for antipyretic, analgesic, antirheumatic and sedative agent agents. This substance has analgesic, anti-inflammatory, and antipyretic properties. But the use is discouraged due to the risk of agranulocytosis.

Lactams have big demand in artificial fibre industry. Pyrazolone derivatives, as lactam structure related compounds, are also widely used in preparing dyes and pigments. 2,4-Dihydro-2-[-4-[(2-hydroxyethyl) sulfonyl] phenyl]-5-methyl-3H-pyrazol-3-one is used as an intermediate for colorants. 

Organosulfur compounds are widely used in refineries, steamcrackers, aromatic extraction and petrochemical manufacturing as they acts as hydrotreating catalysts, initial catalyst improvers, sulfur source and catalyst presulfiding. Sulfoxide (R2SO) is any of various organic sulfur compounds having the group -SO (sulfinyl group) whereas sulfone (RSOOR) with the group -SO2 (sulfonyl group). They are derived from oxidation of sulfides. The common examples of sulfone compounds are dapsone (4,4'-sulfonylbisbenzenamine) and its derivative. Dapsone (4,4'-sulfonylbisbenzenamine) is a parent compound in preparing sulfonamide antibacterial agents such as acedapsone, acetosulfone, glucosulfone, sulfoxone and solapsone. Dapsone and its derivatives have bacteriostatic activity against a broad spectrum of gram-negative and gram-positive organisms. Dapsone is a primary treatment for Dermatitis herpetiformis and in the treatment of leprosy (Mycobacterium leprae infections) leads to apparent improvementas. It is used in the prophylaxis of falciparum malaria. It is a white crystalline powder; melting point 175 - 180C; insoluble in water and vegetable oils. Dapsone is also widely used in polymer industry as a cross linkage agent in manufacturing polysulfone amide engineering plastics. Sulfone-containing engineering plastics are thermally stable and have high resistance property to acids and alkalis. Tazobactam is a penicillanic acid sulfone derivative which acts as a beta-lactamase inhibitor similar to sulbactam. Tazobactam is used in combination with piperacillin to widen the spectrum of activity. Sulfone class compounds which have a sulfonyl group attached to two carbon atoms are active as an antibiotic. 

SALES SPECIFICATION

APPEARANCE

white to off-white powder
ASSAY (G.C) 90.0% min

WATER

3.0% max
TRANSPORTATION
PACKING  
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OTHER INFORMATION
Hazard Symbols: XN, Risk Phrases: 22-36/37/38, Safety Phrases: 26-37/39