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OXYETHYL SULFONE-3-METHYL-5-PYRAZOLONE | ||
PRODUCT IDENTIFICATION |
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CAS NO. | 21951-34-8 |
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EINECS NO. | 244-678-8 | |
FORMULA | C12H14N2O4S | |
MOL WT. | 282.31 | |
H.S. CODE |
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TOXICITY |
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SYNONYMS |
1-[4-(2- Hydroxyethylsulfonyl)phenyl]-3-methyl-5-pyrazolone; |
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2,4-Dihydro-2-[-4-[(2-hydroxyethyl)sulfonyl] phenyl]-5-methyl-3H-pyrazol-3-one; | ||
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CLASSIFICATION |
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PHYSICAL AND CHEMICAL PROPERTIES |
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PHYSICAL STATE | white to off-white powder | |
MELTING POINT |
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BOILING POINT | ||
SPECIFIC GRAVITY | ||
SOLUBILITY IN WATER |
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pH | ||
VAPOR DENSITY |
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AUTOIGNITION | ||
REFRACTIVE INDEX |
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NFPA RATINGS | ||
FLASH POINT | ||
STABILITY | Stable under ordinary conditions. | |
APPLICATIONS |
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Pyrazolone is a five-membered lactam ring compound containing two nitrogens and
ketone in the same molecule. Lactam structure is an active nucleuses in
pharmacological activity. Pyrazolone is an active moiety as a pharmaceutical
ingredient, especially in the class of nonsteroidal antiinflammatory agents used
in the treatment of arthritis and other musculoskeletal and joint disorders.
The term of pyrazolone sometimes refers to nonsteroidal anti-inflammatory agents. Pyrazolone class NSAID (nonsteroidal anti-inflammatory drug) includes phenylbutazone, oxyphenbutazone, dipyrone, and ramifenazone. Antipyrine (also called phenazone) is a pyrazolone class analgesic agent in otic solutions in combination with other analgesic such as benzocaine, and phenylephrine. Antipyrine has been used as an antipyretic, but replaced due to the possibility of agranulocytosis side effect. Lactams have big demand in artificial fibre industry. Pyrazolone derivatives, as lactam structure related compounds, are also widely used in preparing dyes and pigments. 4-Aminoantipyrine possibly can be used as an intermediate for the synthesis of pharmaceuticals especially antipyretic and analgesic drugs. It is also used in the colorimetric determination of phenols. Amidopyrine is used in manufacturing drugs especially for antipyretic, analgesic, antirheumatic and sedative agent agents. This substance has analgesic, anti-inflammatory, and antipyretic properties. But the use is discouraged due to the risk of agranulocytosis. Lactams have big demand in artificial fibre industry. Pyrazolone derivatives, as lactam structure related compounds, are also widely used in preparing dyes and pigments. 2,4-Dihydro-2-[-4-[(2-hydroxyethyl) sulfonyl] phenyl]-5-methyl-3H-pyrazol-3-one is used as an intermediate for colorants. Organosulfur compounds are widely used in refineries, steamcrackers, aromatic extraction and petrochemical manufacturing as they acts as hydrotreating catalysts, initial catalyst improvers, sulfur source and catalyst presulfiding. Sulfoxide (R2SO) is any of various organic sulfur compounds having the group -SO (sulfinyl group) whereas sulfone (RSOOR) with the group -SO2 (sulfonyl group). They are derived from oxidation of sulfides. The common examples of sulfone compounds are dapsone (4,4'-sulfonylbisbenzenamine) and its derivative. Dapsone (4,4'-sulfonylbisbenzenamine) is a parent compound in preparing sulfonamide antibacterial agents such as acedapsone, acetosulfone, glucosulfone, sulfoxone and solapsone. Dapsone and its derivatives have bacteriostatic activity against a broad spectrum of gram-negative and gram-positive organisms. Dapsone is a primary treatment for Dermatitis herpetiformis and in the treatment of leprosy (Mycobacterium leprae infections) leads to apparent improvementas. It is used in the prophylaxis of falciparum malaria. It is a white crystalline powder; melting point 175 - 180C; insoluble in water and vegetable oils. Dapsone is also widely used in polymer industry as a cross linkage agent in manufacturing polysulfone amide engineering plastics. Sulfone-containing engineering plastics are thermally stable and have high resistance property to acids and alkalis. Tazobactam is a penicillanic acid sulfone derivative which acts as a beta-lactamase inhibitor similar to sulbactam. Tazobactam is used in combination with piperacillin to widen the spectrum of activity. Sulfone class compounds which have a sulfonyl group attached to two carbon atoms are active as an antibiotic. |
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SALES SPECIFICATION | ||
APPEARANCE |
white to off-white powder | |
ASSAY (G.C) | 90.0% min | |
WATER |
3.0% max | |
TRANSPORTATION | ||
PACKING | ||
HAZARD CLASS | ||
UN NO. | ||
OTHER INFORMATION | ||
Hazard Symbols: XN, Risk Phrases: 22-36/37/38, Safety Phrases: 26-37/39 |
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